- Englewood Community Hospital
- Englewood Health
- eni Employee Network, Inc.)
- Enka High School
- Enka Middle School
- Enlightened Leadership International
- Enloe Health
- Enloe Medical Center
- Enpath Medical, Inc.
- Enrichment Services Program, Inc.
- Enteray Operations
- Entercom
- Enterprise
- Enterprise Advisory Services Inc. EASI)
- Enterprise Car Rental
- Enterprise Community
- Enterprise Rent-A-Car Hudson Valley Region
- Envelope Manufacturers Association
- Envirocare of Utah
- Environmental Industry Association
- Environmental Systems Research Institute
- Ephraim McDowell Fort Logan Hospital
- Ephraim McDowell James B. Haggin Hospital
- Ephraim McDowell Regional Medical Center
- Epic Design by June Faircloth
- Epic Meetings and Production
- Epic Systems
- Episcopal Ministries to the Aging Inc.
- EPIX Pharmaceuticals
- Eplab Digest
- EPMOD Consultants, Inc.
- Eppstein Uhen Architects
- Epstein, Tabor and Schorr
- Equinoxx Smart Marketing
- Equipment Leasing Association
- Equipo BSN Santeros de Aguada
- Equipo de Voleibol Masulino Criollos de Caguas Inc.
- Equipo do Volleyball Femenino Criollas de Caguas
- eResearch Technology, Inc.
- eResources
- Ergos Technology Partners Inc.
- Erickson Retirement Communities
- Erie 1 Boces
- Erie Community College
- Erie County
- Erie County Convention Center Authority
- Erie County Medical Center
- Erie Insurance Group
- Erie VA Medical Center
- Erlanger Baroness Campus - Erlanger Baroness Hospital and Children's Hospital at Erlanger